IndraLab

Statements

USP6 deubiquitinates JAK1. 4 / 4
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reach
"USP6 works by directly deubiquitinating JAK1, which stabilizes and activates it."
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reach
"To test whether USP6 can induce de-ubiquitination of Jak1 in vivo, HeLa cells were co-transfected with FLAG-Jak1, Myc-Ub, and HA-USP6 alleles."
27440725
trips
"We found that USP6 directly deubiquitinated Jak1, leading to its stabilization and activation of STAT3."
27440725
reach
"We discovered that USP6 was sufficient to directly induce the former two responses via deubiquitination and stabilization of Jak1, leading to phosphorylation and activation of STAT1 (20, 22, 23)."
37615015