IndraLab

Statements

CACNA1A activates Ile-His. 4 / 4
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"Using the spared nerve injury (SNI) model of neuropathic pain in Long-Evans rats and patch-clamp recordings in layer II/III pyramidal neurons of the contralateral mPFC, we observed a hyperpolarizing shift in the voltage-dependent activation of Ih in SNI neurons, whereas maximal Ih remained unchanged."
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"The increase in neuronal excitability persists with continuous PACAP exposure ( xref ; xref ; xref ) and is suggested to be due in part to increased adenylyl cyclase/cyclic AMP levels, which shift the voltage-dependent activation of the nonselective cationic Ih current ( xref ; xref )."
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"Moreover, intracellular application of bromo-cAMP abolished the hyperpolarizing shift in the voltage-dependent activation of Ih observed in SNI neurons, whereas protein kinase A (PKA) inhibition further promoted this shift in both SNI and sham neurons."
26400952
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"In addition, serotonin caused a depolarizing shift in the voltage-dependent activation of Ih."
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