IndraLab

Statements

reach
"The above researchers previously found that USP15 could negatively regulate naive CD4 T cell activation and differentiation into the IFN-γ-producing Th1 cells."
31078284
reach
"Knockdown of USP15 with two different shRNAs markedly inhibited Th17 differentiation (XREF_FIG, top panels and XREF_FIG) compared to knockdown of a close member of USP15, USP45 (XREF_FIG, bottom panels and XREF_FIG)."
27430721
reach
"USP15 inhibits Th1 differentiation in vitro and in vivo in a L. monocytogenes infection model through deconjugating MDM2-mediated ubiquitination of NFATc2 [107] ."
27914308
reach
"Knockdown of USP15 or expression of inactive USP15 attenuates Th17 differentiation, indicating a positive role for USP15-mediated deubiquitination of RORγt in Th17 differentiation."
31078284
reach
"Impaired Th17 differentiation by both inactive C298A and knockdown of USP15 supports the positive role of USP15 in Th17 differentiation."
27430721
reach
"Loss of USP15 promoted Th1 differentiation, but this phenomenon was not observed in CD8 T cells, as explained by the relatively low expression of MDM2 in CD8 T cells."
38715050
reach
"Collectively, these results suggest that USP15 negatively regulates naive CD4 + T cell activation and T H 1 differentiation."
24777531