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USP7 activates Osteoporosis. 4 / 4
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"USP7 promotes the osteoclast differentiation of CD14+ human peripheral blood monocytes in osteoporosis via HMGB1 deubiquitination."
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"We demonstrate that USP7 promotes the differentiation of CD14 + PBMCs into osteoclasts via HMGB1 deubiquitination and that inhibition of USP7 effectively attenuates bone loss in osteoporosis in vivo ."
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"36 Of note , our data revealed that inhibition of proteasome up-regulated expression of USP7 and KDM6B , while increased USP7 expression promoted osteoblast differentiation and autophagy , alleviating osteoporosis ."
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"We demonstrate that USP7 promotes the differentiation of CD14+ PBMCs into osteoclasts via HMGB1 deubiquitination and that inhibition of USP7 effectively attenuates bone loss in osteoporosis in vivo.The translational potential of this article:The study reveals novel insights into the role of USP7 in the progression of osteoporosis and provides a new therapeutic target for the treatment of osteoporosis."
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