IndraLab

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USP22 activates MYC. 13 / 16
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"Furthermore, overexpression of USP22 stimulates breast cancer cell growth and colony formation, and increases c-Myc tumorigenic activity."
28160502
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"While these outcomes could occur via USP22 mediated MYC and CyclinD2 and/or BMI-1-mediated modulation, AR activity promotes tumorigenesis in several of these tumor types, including bladder, HCC and breast carcinoma."
24197134
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"USP22 depletion in the lung cancer cells decreases the transcriptional ability of Myc [4]."
31689236
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"In this study, we found that USP22 overexpression induces c-myc upregulation in both SGC7901 cells and tumor tissue, consistent with previous reports."
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"Evidently, HnRNPA1 is a downstream transcription regulator of c-Myc (proto-oncogene) whereas USP22 positively regulates c-Myc stability and promotes tumorigenesis [XREF_BIBR, XREF_BIBR]."
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"C-Myc abundance is also indirectly increased by the activity of USP22 on its substrate SIRT1, a NAD dependent protein deacetylase [XREF_BIBR] (see Section 7), but this is not observed in all cell types [XREF_BIBR]."
29210986
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"Decreased levels of USP22 reduce the ability of c-MYC, which can stimulate activation of AP4 to directly or indirectly induce EMT [XREF_BIBR], activating the transcription of its targets [XREF_BIBR, XREF_BIBR]."
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"USP22 increases the stability and tumorigenic activity of c-Myc in breast cancer cells [30]."
31689236
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"In addition, USP22 expression was shown to increase the abundance of c-Myc and the androgen receptor itself [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
29210986
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"Studies herein suggest that USP22 mediated MYC regulation in PCa is likely gene selective, based on USP22 increasing gene expression of AR/MYC co-regulated target (ODC) but not of multiple MYC targets."
24197134
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"USP22 increased c-Myc stability via deubiquitination in breast cancer cells."
33643919
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"Deubiquitinating enzyme USP22 positively regulates c-Myc stability and tumorigenic activity in mammalian and breast cancer cells."
28160502
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"In conclusion, the present study reveals that USP22 in breast cancer cell lines increases c-Myc stability through c-Myc deubiquitination, which is closely correlated with breast cancer progression."
28160502