IndraLab

Statements

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"In vivo studies on a NZB/W F1 murine model of lupus showed that HCQ in combination with PRD (2.5 mg/kg/day and 1 mg/kg/day p.o.) decreased autoantibody production, as well as being able to inhibit toll like receptor activation, resulting in the down-regulation of type I interferon (IFN-alpha) which is deeply implicated in lupus pathogenesis."
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"Hydroxychloroquine has been shown to inhibit toll like receptor pathways, thus dampening antigen presenting cells from activating inflammatory processes (6)."
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"HCQ inhibits toll like receptor signaling (which plays a critical role in the immune response), and it is prescribed for pregnancies involving a high risk of CAVB."
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"Hydroxychloroquine inhibits toll like receptor signaling and exerts antithrombotic and antihyperlipidemic effects, all thought to be beneficial in systemic lupus erythematosus."
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"Hydroxychloroquine can increase the endosomal pH, inhibit the toll like receptor activity and interfere with the terminal glycosylation of ACE-2 [XREF_BIBR]."
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"Hydroxychloroquine is thought to work in part by increasing lysosomal pH in antigen presenting cells, reducing toll like receptor signaling resulting in decreased activation of dendritic cells and through the reduction of interferon production, amongst other mechanisms."
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"Leflunomide inhibits pyrimidine synthesis, thus reducing lymphocyte proliferation [13], whilst hydroxychloroquine reduces immune responses [14] by inhibiting the toll-like receptor signalling [15]."
| PMC
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"Hydroxychloroquine increases lysosomal pH in antigen presenting cells and decreases toll like receptor signaling, features that make it an attractive drug for chronic inflammatory conditions like rheumatoid arthritis."
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