IndraLab

Statements

USP30 inhibits mutated PRKN. 3 / 3
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"Early studies on USP30 focused on reversal of Parkin dependent MOM ubiquitylation in HeLa cells overexpressing Parkin, as well as in Drosophila, where reduction in USP30 function enhanced the activity of Parkin mutants."
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"Strikingly, knockdown of USP15 or USP30 causes enhanced degradation of depolarized mitochondria in cells expressing wild-type Parkin, and furthermore rescues mitophagy defects in cells expressing path[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, loss of USP30 can promote the activity of mutant Parkin alleles."
32142685