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BAP1 binds OGT. 37 / 38
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"Consistent with previous reports [2,5,7] , the endogenous interaction between BAP1 and OGT was confirmed by IP with the anti-BAP1 antibody and WB analysis using the anti-OGT antibody in HEK293 cells ([MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28802580
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35446349
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32509391
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26416890
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19615732
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"Likewise, our finding of the BAP1–OGT interaction prompted us to address whether BAP1 is O -GlcNAcylated by OGT."
28802580
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"Consistent with previous reports [2,5,7] , the endogenous interaction between BAP1 and OGT was confirmed by IP with the anti-BAP1 antibody and WB analysis using the anti-OGT antibody in HEK293 cells ([MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28802580
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"In this study, we confirmed that BAP1 interacts with OGT in vivo and investigated the biological significance of this interaction."
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"Knock-in mice expressing BAP1 with a 3xFlag tag revealed that BAP1 interacts with HCF-1, OGT, and the polycomb group proteins ASXL1 and ASXL2 in vivo."
22878500
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"Further biochemical experiments revealed that Ser576 phosphorylation inhibits Lys604 ubiquitination by stimulating OGT binding with BAP1, a de-ubiquitinase for OGT."
40571812
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"In sum, we found that ULK1 phosphorylates OGT at Ser-576 under glucose deprivation, which stabilizes OGT by promoting OGT-BAP1 association and is pivotal for O-GlcNAcylation levels and tumorigenesis."
40571812
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27705803
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"To further refine the connectivity of OGT1 within the PR-DUB network, we performed AP-MS experiments using OGT1 as bait.This analysis validated the interaction between BAP1 and OGT1 and the interactio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27705803
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"Hence, we further proceeded to investigate the role of OGT on the stability of nuclear BAP1.To confirm the physical association between BAP1 and OGT in HCC, co-immunoprecipitation (co-IP) assays using BAP1 antibody and endogenous nuclear proteins from PLC/PRF/5 was performed."
39984455
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"On the other hand, we uncovered that O-linked N-acetylglucosamine (GlcNAc) transferase (OGT) physically bound to BAP1 in the nucleus, resulting in diminished stability of the nuclear BAP1."
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"On the other hand, we found that OGT physically bound BAP1 and negatively regulated BAP1 stability in the nuclei of HCC cells in an O-GlcNAcylation independent manner."
39984455
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"OGT physically bound BAP1 and maintained BAP1 nuclear localization in HCC cells."
39984455
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"From the experiments, we demonstrated the direct interaction between BAP1 and OGT using in vitro GST-pull down assay followed with mass spectrophotometry, and the data was in accordance with previous report that OGT binds BAP1 protein [ xref ]."
39984455
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"The results positively showed that BAP1 was physically associated with OGT in the nucleus (Fig. xref )."
39984455
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"To investigate their transcriptional control, we extracted the ChIP sequencing data from the Encyclopedia of DNA Elements data portal [ xref ] to search putative transcription factors which physically interact with BAP1 and OGT promoter region in context of liver tissue or in HepG2 cells."
39984455
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"On the other hand, we found that OGT physically bound BAP1 and negatively regulated BAP1 stability in the nuclei of HCC cells in an O-GlcNAcylation independent manner."
39984455
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"A study has reported that OGT physically interacts with the C-terminus region of BAP1, and this might mask the putative nucleus localization of BAP1, resulting in maintenance of cytoplasm subcellular localization in HCC cells [ xref , xref ]."
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"BAP1 interaction with the OGT/HCF-1 complex and PGC-1α, suggests a potential role for BAP1 in regulating cellular metabolism ."
39191942
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"BAP1 interacts with OGT in the PR-DUB complex, and our data suggest that the PR-DUB complex plays a multifunctional role in repression of the injury program."
36790040
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"BAP1 interacts with OGT as subunits of the PR-DUB complex ( xref , xref ), and a Schwann-cell specific Ogt KO mouse model exhibited deficient remyelination after injury that was traced to the premature activation of JUN in uninjured nerve ( xref , xref )."
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"These results indicate that the OGT-BAP1 complex may function independently from the OGT-SET1/COMPASS complex.We next investigated whether OGT activity toward substrates proximal to BAP1 in the network was decoupled from other substrates."
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"The gene expression changes are similar in several respects with previous analysis of a Schwann cell knockout of OGT, which interacts with BAP1 in the PR-DUB complex."
36790040
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"Accordingly, OGT is less tightly associated with BAP1 compared to other PR-DUB subunits and can participate in other complexes ( xref , xref )."
36790040
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"On the other hand, we uncovered that O-linked N-acetylglucosamine (GlcNAc) transferase (OGT) physically bound to BAP1 in the nucleus, resulting in diminished stability of the nuclear BAP1."
39984455
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No evidence text available
27705803
reach
"OGT physically bound BAP1 and maintained BAP1 nuclear localization in HCC cells."
39984455
reach
"From the experiments, we demonstrated the direct interaction between BAP1 and OGT using in vitro GST-pull down assay followed with mass spectrophotometry, and the data was in accordance with previous report that OGT binds BAP1 protein [20]."
39984455
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"These results indicate that the OGT-BAP1 complex may function independently from the OGT-SET1/COMPASS complex."
37398272
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No evidence text available
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