IndraLab

Statements

SETD7 methylates OTUB1 on K122. 8 / 8
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"Taken together, these data suggest that SET7 interacts with OTUB1 to catalyze monomethylation of OTUB1 at K122."
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"Here, we found that K122 of OTUB1 methylated by SET7 could affect OTUB1 binding to UBC13 obviously."
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sparser
"Here, we found that K122 of OTUB1 methylated by SET7 could affect OTUB1 binding to UBC13 obviously."
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"So, it is still enigmatic why K122 of OTUB1 methylated by SET7 could impair OTUB1 binding to UBC13."
36822329
sparser
"So, it is still enigmatic why K122 of OTUB1 methylated by SET7 could impair OTUB1 binding to UBC13."
36822329
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"Further assays show that SET7 mediated the monomethylation of OTUB1 on lysine 122, leading to the impairment of its binding to UBC13 and the relief of its suppressive role on ferroptosis."
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"SET7 directly interacts with OTUB1 to methylate OTUB1 on lysine 122."
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"Subsequently, we examined whether OTUB1 methylation at K122 was mediated by SET7."
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