IndraLab

Statements

Ethanol inhibits CASP1. 12 / 14
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"Ethanol Inhibits Activation of Caspase-1."
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"Alcohol buildup has been reported to inhibit caspase-1 and increase the production of IL-18 and IL-1 in esophageal epithelial cells, both of which are associated with pyroptosis [57]."
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"These findings suggest that ethanol inhibits the autoproteolysis of caspase-1 by inhibiting the activation of inflammasome."
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"Ethanol prevents the cleavage of pro-IL-1beta and pro-caspase-1 into their mature forms."
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"In the development of esophageal cancer, alcohol consumption has been shown to inhibit caspase-1 and promote IL-18 and IL-1β and has been associated with pyroptosis 59."
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"Our data further suggest that FBXL2, an E3 ubiquitin ligase associated with mitochondrial homeostasis and mitophagy, is destabilized due to proteasomal degradation of caspase-1 by ethanol-induced hyperactivation of NLRP3-caspase-1 inflammasome signaling, resulting in mitochondrial injury and apoptosis."
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"A. absinthium flower and leaf ethanol extracts significantly lowered caspase-1 (p < 0.001) but with no significant differences between dilutions."
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"And, similar to J774 cells, ethanol treatment prevented the cleavage and secretion of both IL-1beta and caspase-1 from human PBMCs (XREF_FIG)."
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"In addition, alcohol reduced pro caspase 1 but promoted caspase 1 activation in mice with tumors."
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"In line of this hypothesis, here we found that ethanol induced activation of Caspase-1, as well as cleavage of IL-1beta were attenuated in livers of MyD88 LysM-KO mice, suggesting that Myeloid-MyD88 contributes to ethanol induced liver injury through induction of pyroptosis."
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"The additional application of EtOH to sodium orthovanadate at the first time point significantly decreased the caspase-1 activity, but less so than EtOH does in the LPS and ATP group."
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"Ethanol Diminishes Caspase-1 Activity and ASC Speck Formation In order to investigate the influence of ethanol on caspase-1 activation , EtOH was applied to HepG2 cells at two different time points to determine its mechanistical approach ."
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