IndraLab

Statements

UCHL1 decreases the amount of BACE1. 4 / 5
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"This study suggests that potentiation of UCHL1 might be able to reduce the level of BACE1 and Abeta in brain, which makes it a novel target for AD drug development."
22212137
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"Thus, the restoration of Uch-L1 was able to completely prevent both the increase in BACE1 protein levels and the amount of cell death."
29033830
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"We found that inhibition of UCHL1 significantly increased BACE1 protein level in a time dependent manner."
22212137
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"The restoration of Uch-L1 was able to completely prevent the increase of BACE1 protein levels both in control and Tg mice at 6 h post injury, as reported by the representative blot and by the densitometric analysis."
29033830