IndraLab

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NKX2-5 decreases the amount of HCN4. 7 / 7
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"The results revealed that Nkx2.5 silencing increased HCN4 expression, decreased Cx40 expression and disrupted the expression of calcium handling proteins."
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"Nkx2.5 silencing increased HCN4 expression, decreased Cx40 expression and caused disturbance in the expression of calcium handling proteins."
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"Loss of Nkx2.5 leads to more pacemaker-like myocardial tissue, therefore increasing expression of Hcn4 but reducing levels of Cx40."
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"During embryogenesis, Pitx2c was shown to synergistically drive expression of natriuretic peptide A (Nppa) in the presence of the homeobox transcription factor, Nkx2.5 which in turn, suppressed the expression of the pacemaker channel gene, Hcn4, and the T-box transcription factor (Tbx3), gene, thus delineating contractile atrial myocardium from the sinoatrial node."
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"During heart tube maturation, Nkx2.5 progressively represses expression of Hcn4, resulting in molecular delineation of a distinct, compact SA node region in the right atrium."
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"Nkx2.5 in the atrial myocardium suppresses the expression of pacemaker channel gene Hcn4 and T-box transcription factor Tbx3, restricting their expression domain to the forming Nkx2.5-negative sinoatrial node and sinus horns and defining a gene expression boundary between the atrium and SA node."
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"Moreover, the downregulation of Hcn4 is unlikely to be due to reduced Nkx2-5 levels, as Nkx2-5 has been reported to negatively regulate Hcn4 gene expression ."
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