IndraLab

Statements

BAP1 activates DDR. 6 / 6
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eidos
"Thus , BAP1 is thought to modulate DDR through H2Aub ."
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"BAP1 can modulate the DDR via several different interactions , including deubiquitinylation of histone H2A ( 6 , 7 ) ."
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"Thus, BAP1 is thought to modulate DDR through H2Aub."
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"Indeed, inhibition of BAP1 by short hairpin RNAs (shRNAs) impaired the DDR and caused HeLa cells to become hypersensitive to ionizing radiation resulting in S-phase retardation, a phenotype similar to BRCA1 deficiency."
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"In such an environment, an impaired DDR caused by BAP1 deletion, might be expected to favour the accumulation of genetic damage that eventually gives rise to a malignant clone."
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"BAP1 can modulate the DDR via several different interactions, including deubiquitinylation of histone H2A."
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