IndraLab

Statements

PNLIP inhibits USP7. 4 / 4
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"Here, we report that sesquiterpene lactone parthenolide (PTL) inhibits USP7 activity, assessed with deubiquitinating enzyme activity assays, including fluorogenic Ub-AMC and Ub-Rho 110, Ub-VME/PA labeling and Di-Ub hydrolysis assays."
32029476
sparser
"These data gave us a hint that the inhibition of USP7 by PTL may improve the sensitivity of ATO."
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"These data gave us a hint that the inhibition of USP7 by PTL may improve the sensitivity of ATO."
36353537
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"In summary, our findings reveal that PTL inhibits USP7 activity, identifying a potential mechanism by which PTL suppresses Wnt and beta-catenin signaling."
32029476