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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

IAPP decreases the amount of UCHL1. 1 / 1

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"One of the factors associated with dysfunctional proteasome activity is mediated by the accumulation of IAPP, which lowers the expression of UCH-L1 protein (ubiquitin hydrolase), leading to ER stress and increased levels of cleaved caspase 3, activating apoptosis [XREF_BIBR]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...