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IAPP decreases the amount of UCHL1. 1 / 1
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"One of the factors associated with dysfunctional proteasome activity is mediated by the accumulation of IAPP, which lowers the expression of UCH-L1 protein (ubiquitin hydrolase), leading to ER stress and increased levels of cleaved caspase 3, activating apoptosis [XREF_BIBR]."