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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

USP1 activates Neoplasm Invasiveness. 4 / 4

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"USP1 enhances the expression of a number of pro metastatic genes in breast cancer cells, promotes cell migration and invasion in vitro, and facilitates lung metastasis of breast cancer cells."

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"Overexpression of USP1 promoted cell proliferation, apoptosis, migration and invasion, and decreased cell chemo-sensitivity; however, it could be partially reversed via the overexpression of miR-192-5p in osteosarcoma cell lines."

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"Gene silencing of USP1 by lentivirus effectively inhibits proliferation and invasion of human osteosarcoma cells."

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"It remains to be investigated if our small molecule inhibitors of USP1 can reduce the invasiveness of leukemic cells."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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Statements

USP1 activates Neoplasm Invasiveness. 4 / 4

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