IndraLab
Statements
USP1 activates Neoplasm Invasiveness. 4 / 4
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"USP1 enhances the expression of a number of pro metastatic genes in breast cancer cells, promotes cell migration and invasion in vitro, and facilitates lung metastasis of breast cancer cells."
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"Overexpression of USP1 promoted cell proliferation, apoptosis, migration and invasion, and decreased cell chemo-sensitivity; however, it could be partially reversed via the overexpression of miR-192-5p in osteosarcoma cell lines."
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"Gene silencing of USP1 by lentivirus effectively inhibits proliferation and invasion of human osteosarcoma cells."
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"It remains to be investigated if our small molecule inhibitors of USP1 can reduce the invasiveness of leukemic cells."