IndraLab

Statements

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"They used a PI3K inhibitor (S2793) to reverse the effects of USP1 and found that USP1 overexpression activated the PI3K/AKT signaling pathway, causing tumor cell migration and invasion in HNSCC (92,99)."
40337608
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"USP1 Overexpression Promotes Cell Proliferation, Migration, and Invasion."
39513905
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"Moreover, Transwell assays showed that USP1 deficiency repressed the migration and invasion of UMUC3 cells (Figure 3D,E)."
39513905
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"Additionally, USP1 affects tumor stem cell properties and increases tumor invasiveness and recurrence risk by regulating the degradation of key transcription factors [34]."
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"USP1 enhances the proliferation, invasion, and metastasis of CCA by stabilizing PARP1."
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"USP1 knockdown inhibits their proliferation, migration, and invasion [17,18]."
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"Inhibition of USP1 by ML323 suppressed proliferation, migration and invasion of OS cell lines."
35637948
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"USP1, OUTB1, and USP11 induced migration, invasion, and metastasis through Snail (Figure 2B) [109,111,112]."
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"Gene silencing of USP1 by lentivirus effectively inhibits proliferation and invasion of human osteosarcoma cells."
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"Transwell assays presented that USP1 overexpression markedly promoted migration and invasion of GC cells (Fig. 6k, m, Supplementary Fig. S6f, h), while its knockdown exerts opposite effects (Fig. 6l, n, Supplementary Fig. S6g, i)."
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"USP1 enhances the expression of a number of pro metastatic genes in breast cancer cells, promotes cell migration and invasion in vitro, and facilitates lung metastasis of breast cancer cells."
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"Silencing of USP1 inhibited cell proliferation and invasion through reducing expression of some downstream proteins, including Notch signaling pathway."
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"In breast cancer, the upregulation of USP1 expression and deubiquitination of KPNA promotes cell proliferation, migration, and invasion in vitro and promotes lung metastasis of breast cancer cells [13]."
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"It remains to be investigated if our small molecule inhibitors of USP1 can reduce the invasiveness of leukemic cells."
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"In U2OS cells (a human OS cell line), silencing USP1 attenuated U2OS proliferation and invasion 17."
35637948
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"USP1 increases BC cell migration and invasion in vitro."
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"Furthermore, suppression of USP1 impedes the invasion of HCCC-9810 and HuCC-T1, whereas upregulation of USP1 promotes invasion in RBE cell line."
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"Taken together, these findings revealed that inhibition of USP1 by ML323 inhibits proliferation, migration, and invasion in OS cell lines."
35637948
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"USP1 silencing suppressed ESCC cell proliferation, invasion, and immune escape, which were reversed by CXCR4 overexpression."
39440461
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"Silencing USP1 in U2OS cells (a human OS cell line) attenuated U2OS proliferation and invasion 17."
35637948
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"It was found that compared to cells transfected with S2739 alone, the USP1 OE group significantly promoted tumor cell proliferation, migration and invasion, but inhibited tumor cell apoptosis."
34626803
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"The phenotype results suggested that USP1 promoted cell proliferation, migration, and invasion."
39513905
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"Overexpression of USP1 promoted cell proliferation, apoptosis, migration and invasion, and decreased cell chemo-sensitivity; however, it could be partially reversed via the overexpression of miR-192-5p in osteosarcoma cell lines."
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"Ectopic expression of USP1 statistically enhanced cell proliferation, migration and invasion abilities and decreased cell apoptosis and chemo-sensitivity in 143B and U2OS cells."
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