IndraLab

Statements

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"In addition, roxithromycin inhibits hERG channels and disrupts hERG protein trafficking [XREF_BIBR]."
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"In addition, roxithromycin inhibits hERG channels and disrupts hERG protein trafficking [ xref ] (Table xref )."
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"Roxithromycin was found to inhibit wild-type (WT) hERG currents in a concentration dependent manner with a half-maximum block concentration (IC50) of 55.8 +/- 9.1 mumol/L."
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"Roxithromycin also inhibited the trafficking of hERG protein to the cell membrane, as confirmed by Western blot analysis and confocal microscopy."
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"Mutations in drug binding sites (Y652A or F656C) of the hERG channel were found to attenuate hERG current blockage by roxithromycin, but did not significantly alter the disruption of trafficking."
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