IndraLab

Statements

OTUB1 activates HSF1. 14 / 14
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"In summary, OTUB1 promotes the development of endometriosis by up-regulating HSF1."
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"OTUB1 promotes the protein stability of HSF1 through deubiquitination."
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"The results showed that OTUB1 overexpression increased the abundance of HSF1 in a dose-dependent manner in HEK293T cells (Figures 2A and 2B)."
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"And OTUB1 promoted HSF1 protein stability in dependence on its deubiquitinating enzyme activity (Figure 2C)."
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"In addition, overexpression of OTUB1 promoted the abundance of HSF1 in 11Z and HESC cells (Figure 2D)."
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"As we expected, OTUB1 prolonged the half-life of HSF1 in HEK293T cells (Figure 2H)."
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"Currently, the only deubiquitinating enzyme of HSF1 reported is OTUB1, which promotes the proliferation and invasion of endometrial cells by promoting the protein stability of HSF1 through its deubiquitination [41], and they are colocalized in both the cytoplasm and nucleus."
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"OTUB1 promoted the protein stability of HSF1 through deubiquitination and prolonged its half-life."
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"Therefore, we overexpressed OTUB1 in HEK293T cells and treated them with cycloheximide or proteasome inhibitors to determine whether the inhibition of the proteasome could abolish OTUB1-mediated stability of HSF1 protein."
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"Here, we demonstrate that OTUB1 interacts with HSF1 and promotes HSF1 protein stability through deubiquitination."
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"In summary, OTUB1 promotes the HSF1 protein stability through the deubiquitination pathway."
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"In addition, OTUB1 promoted the transcriptional activity of HSF1."
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"OTUB1 promoted the protein stability of HSF1, so we next determined whether OTUB1 could regulate HSF1-mediated transcription."
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"Thus, OTUB1 enhances the transcriptional activity of HSF1."
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