IndraLab

Statements

Thapsigargin activates KCNH2-E637K. 2 / 2
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"Moreover, our study is the first to demonstrate that thapsigargin fails to rescue the dominant negative suppression of the E637K hERG mutant on WT-hERG channel function."
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"However, our study shows that thapsigargin fails to rescue trafficking defects of the E637K hERG mutant, which is a novel missense mutation located in the pore-S6 loop transmembrane segment of hERG, nearby the C-terminus XREF_BIBR."
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