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NANOG activates USP25. 2 / 2

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"Interestingly, we also noticed that co-expression of MEK1 CA and ERK resulted in the band shift of both Nanog and USP21 (XREF_SUPPLEMENTARY), which is possibly caused by the phosphorylation of Nanog and USP21 by the activated ERK."

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"Moreover, depletion of USP21 by shRNAs in mESCs significantly increased the ubiquitination of endogenous Nanog (XREF_FIG), indicating that endogenous Nanog was also a target of USP21."

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IndraLab

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NANOG activates USP25. 2 / 2

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