IndraLab

Statements

USP2 activates LDLR. 3 / 5
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reach
"Conversely, loss of USP2 reduces LDLR protein in an IDOL dependent manner and limits LDL uptake."
26666640
reach
"USP2 not only interacts with and stabilises the sterol regulated E3-ligase IDOL but also rescues LDLR from lysosomal degradation, recalling the example of USP7 described in detail below 53."
28064438
reach
"USP2 promoting LDLR activity was not simply an artefact of overexpression, as convincingly demonstrated by the Usp2 siRNA experiments, which showed a 70% reduction in surface LDLR levels and a halving of LDL uptake."
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