IndraLab

Statements

YOD1 binds TRAF6, TRAF, and BLNK. 2 / 2
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"YOD1 binds to the C-terminal TRAF homology domain of TRAF6 that also serves as the interaction surface for the adaptor p62/Sequestosome-1, which is required for IL-1 signaling to NF-κB. We show that YOD1 competes with p62 for TRAF6 association and abolishes the sequestration of TRAF6 to cytosolic p62 aggregates by a non-catalytic mechanism."
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"In addition, YOD1 can bind to the C-terminal TRAF homology domain of TRAF6, which also serves as the interaction surface for the adaptor p62/Sequestosome-1required for IL-1 signaling to NF-κB. Interestingly, the NF-κB pathway is closely related to CAD xref , xref ."
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