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YOD1 deubiquitinates ZNF24. 5 / 5
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"Our results reveal the mechanism by which YOD1 regulates VEGFA transcription and suppresses tumorigenesis by deubiquitinating ZNF24, providing a therapeutic target in ccRCC."
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"Given that YOD1 is a component of the OTU family of DUBs, we investigated whether YOD1 deubiquitinates ZNF24."
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"Moreover, ZNF24 polyubiquitination was dose-dependently suppressed by overexpression of wild-type YOD1 (Fig. 5B)."
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"Conversely, YOD1 knockdown significantly increased the level of ZNF24 polyubiquitination in both HEK-293T cells and ccRCC cell lines (A498 and 786-O) (Fig. 5D–F)."
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"Notably, the deubiquitination of ZNF24 by YOD1 was dependent on its OTU enzyme active site, as the YOD1-C160S mutant did not deubiquitinate ZNF24."
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