Other Services

This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TP53-R175H increases the amount of TP53. 2 / 2

| 2

➶

reach

"DAXX also reduced protein, but not mRNA, levels of p53(R175H) in H1299 cells that inducibly express this mutant and increased the expression of p53 target genes including p21 and Puma (Extended Data Figs."

34408321

➶

reach

"Although there was no significant difference in expression of CDKN1A, VDR, and TP53INP1 between CD24 + PC3 cells and CD24 - PC3 cells, the transfections of WT TP53, mutants TP53 R273H, TP53 V143A, and TP53 R280T, but not mutant TP53 R175H, induced the expression of these p53 target genes in CD24 - PC3 cells but not in CD24 + PC3 cells (XREF_FIG)."

26712693

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...