IndraLab

Statements

UCHL1 activates TYMS. 3 / 3
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"Interestingly, we found that the TS mRNA and protein levels were remarkably upregulated in the two PEM-R cell lines, and were significantly reduced by UCHL1 silencing or inhibition."
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"While the present study revealed that UCHL1 increased TS mRNA and protein expression, without any affections on TS enzyme activity (per pmol), and the underlying mechanisms remain unclear."
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"Conclusions : It appears that UCHL1 promotes PEM resistance by upregulating TS in NSCLC cells, which mitigated DNA damage and cell cycle arrest."
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