IndraLab
Statements
reach
"A possible, but one-sided explanation may be that normal physiological concentrations of Twist1 individually inhibit USP13 promoter activation, whereas abnormal expression of USP13 may induce Twist1 to recruit co-factors to promote the transcription of its target genes including USP13."
reach
"USP13 has been shown to upregulate fatty acid synthase (FASN) to promote the proliferation of SCLC cells and Twist-related protein 1 (Twist1) to promote the migration and invasion of breast cancer cells, while it inhibits cell proliferation via downregulation of glycolysis in oral squamous cell carcinoma (47,48)."