IndraLab

Statements

IE1 activates TNFAIP3. 6 / 6
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"Although A20 has been shown to be induced during HCMV entry, we also found that IE1 activates the A20 promoter through the upstream NF-κB sites."
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"These results indicate that IE1 activates the A20 promoter through the NF-κB sites in reporter assays."
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"The results of similar transfection assays showed that IE1 activated the wild-type A20 promoter by 32-fold but upregulated the NF-κB mutant version by only 6-fold, whereas IE2 did not significantly affect IE1 activity (Figure  xref C)."
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"We also found that IE1 activates the A20 promoter."
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"The direct activation of A20 promoter by IE1 is not surprising, since IE1 induces NF-κB activity and the A20 promoter contains two NF-κB binding sites."
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"We also found that the viral IE1 protein activates the A20 promoter through the upstream NF-κB biding sites, suggesting a role of IE1 in the initial A20 activation."
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