IndraLab

Statements

TNF increases the amount of ABCA1. 8 / 9
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"In cultivated HBP, TNFα activates the LXR pathway and increases the expression of one of its target genes, the transporter ATP-binding cassette family A member 1 ( ABCA1 ), while ABCG1 is not expressed."
36983062
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"The expression of ABCA1 was increased by 5 ng/ml or 10 ng/ml TNF-alpha compared with control group, and was inhibited by 20 ng/ml TNF-alpha."
18155667
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"However, the role for TNF remains controversial since other studies have shown that TNF enhances ABCA-1 expression and the efflux of cholesterol in peritoneal macrophages stimulated with ApoA-I and since evidences from studies performed in murine models are also contentious."
29375564
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"Interestingly, TNFalpha treatment increased ABCA1 promoter activity and ABCA1 mRNA levels, and increased liver X receptor alpha protein expression, but had no effect on retinoid X receptor alpha and retinoic acid receptor alpha levels."
26759003
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"Therefore they concluded that TNF-alpha signaled primarily through NF-kappaB to induce ABCA1 expression in macrophages."
22750628
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"Thus, TNFalpha signals primarily through NF-kappaB to induce ABCA1 expression in macrophages."
16492740
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"However, TNFα can also increase ABCA1 expression in macrophages."
33882688
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"In our study, the induction of ABCA1 expression by TNF-alpha was prevented by pre-treatment of GW9662."
18155667