IndraLab

Statements

TNF increases the amount of ABCA1. 17 / 18
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"It has been shown that TNF can decrease HDL cholesterol levels by attenuating the expression of ABCA1 cholesterol efflux transporter [40] ."
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"TNF-α promotes atherosclerosis by downregulating ABCA1 and G1 protein expression, which impairs reverse cholesterol transport, and upregulating CD36 and SR-A1, which enhances cholesterol uptake [39,40]."
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"One goal of this study was to test the hypothesis that TNF increases ABCA1 expression and cholesterol export potential and that this is mediated through the action of TNFR1."
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"Therefore they concluded that TNF-alpha signaled primarily through NF-kappaB to induce ABCA1 expression in macrophages."
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"Because LT is also a ligand for the TNFRs [11] , we tested the hypothesis that LT is able to modulate macrophage ABCA1 expression.Overall, we confirm an earlier report that TNF induces ABCA1 mRNA and [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These data demonstrate that TNF increases expression and activity of ABCA1, confirming an earlier report [12] ."
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"In cultivated HBP, TNFalpha activates the LXR pathway and increases the expression of one of its target genes, the transporter ATP-binding cassette family A member 1 (ABCA1), while ABCG1 is not expressed."
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"We further demonstrate that LT modulates the extent of ABCA1 protein degradation, at least in cells devoid of TNFRs, acting through the LTβR. TNF and LT are likely involved in protection from atherosc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Indeed, whereas TNFα increased ABCA1 expression by 1.5-fold at 24 h, T0901317 increased ABCA1 expression by 34-fold."
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"However, this role for TNF-α remains controversial since two other studies have shown TNF-α enhances ABCA-1 expression and ApoA–I stimulated cholesterol efflux in murine peritoneal macrophages (MPMs) [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, TNFα can also increase ABCA1 expression in macrophages."
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"For the first time, we demonstrated in human brain pericytes that TNFα triggers the LXR signaling pathway, thus enhancing the ABCA1 expression that correlates with a lower cholesterol intracellular accumulation and an increase of the cholesterol efflux to HDL, APOA-I, APOE2 and APOE4."
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"In our study, the induction of ABCA1 expression by TNF-alpha was prevented by pre-treatment of GW9662."
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"Interestingly, TNFalpha treatment increased ABCA1 promoter activity and ABCA1 mRNA levels, and increased liver X receptor alpha protein expression, but had no effect on retinoid X receptor alpha and retinoic acid receptor alpha levels."
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"However, the role for TNF remains controversial since other studies have shown that TNF enhances ABCA-1 expression and the efflux of cholesterol in peritoneal macrophages stimulated with ApoA-I and since evidences from studies performed in murine models are also contentious."
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"Thus, TNFalpha signals primarily through NF-kappaB to induce ABCA1 expression in macrophages."
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"For example, TNF-α attenuates HDL biogenesis by reducing the expression of the cellular cholesterol transporter ABCA1."
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