IndraLab

Statements

USP12 decreases the amount of Chemokine. 3 / 3
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"The literature indicates that USP12 has been shown to diminish T-cell activation by facilitating the expression of specific chemokines."
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"In terms of NSCLC, USP12 was decreased upon the activation of AKT-mTOR signaling, and USP12 could reduce the levels of several chemokines, including CXCL8, CXCL1, CCL2, and CCL5, which were relevant to immune cell recruitment."
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"Given that USP12 negatively regulated protumourigenic chemokine expression and exerted a tumour-suppressive effect in immune-competent mice but not in immune-deficient mice, it seems intuitive to speculate that USP12 downregulation in tumours may help establish a favourable microenvironment for tumour growth."
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