IndraLab

Statements

MTX1 activates KCNH2. 7 / 7
| 5 2
reach
"MTX increased both step and tail hERG currents with EC (50) values of 0.34 and 0.52 microM, respectively."
16928897
sparser
"We conclude that MTx and KB130015 synergically activate hERG1 channels, requiring the existence of at least two functionally coupled activator sites."
20097192
reach
"We conclude that MTx and KB130015 synergically activate hERG1 channels, requiring the existence of at least two functionally coupled activator sites."
20097192
reach
"In addition, MTX increased hERG deactivation time constants."
16928897
reach
"Similar to KB130015, mallotoxin (MTx) activates the hERG1 channel by shifting its voltage dependence to the left and by accelerating activation."
20097192
reach
"In conclusion, MTX activates hERG channels through distinct mechanisms and with significantly higher potency than previously reported hERG channel activators."
16928897
sparser
"In conclusion, MTX activates hERG channels through distinct mechanisms and with significantly higher potency than previously reported hERG channel activators."
16928897