IndraLab

Statements


MTX1 activates KCNH2. 7 / 7
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sparser
"In conclusion, MTX activates hERG channels through distinct mechanisms and with significantly higher potency than previously reported hERG channel activators."

sparser
"We conclude that MTx and KB130015 synergically activate hERG1 channels, requiring the existence of at least two functionally coupled activator sites."

reach
"Similar to KB130015, mallotoxin (MTx) activates the hERG1 channel by shifting its voltage dependence to the left and by accelerating activation."

reach
"We conclude that MTx and KB130015 synergically activate hERG1 channels, requiring the existence of at least two functionally coupled activator sites."

reach
"MTX increased both step and tail hERG currents with EC (50) values of 0.34 and 0.52 microM, respectively."

reach
"In addition, MTX increased hERG deactivation time constants."

reach
"In conclusion, MTX activates hERG channels through distinct mechanisms and with significantly higher potency than previously reported hERG channel activators."