IndraLab

Statements

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"Inhibition of UCH-L1 by LDN Leads to MT Reorganization and Stabilization in Oligodendroglial Cells."
25999815
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"UCHL1 inhibition by LDN activates autophagic pathway in both an alpha-synuclein overexpressed oligodendroglial cell line [ 23 ] and an alpha-synuclein transgenic mouse model [ 24 ]."
29462615
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"A previous study described that UCHL1 plays an important role in neurodegenerative diseases, and inhibition of UCHL1 by LDN caused the up regulation of the autophagic pathways and the clearance of alp[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29462615
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"In this study, we examined the effect of UCHL1 inhibition by LDN, a specific inhibitor, on the development of AF in a murine model of Ang II-induced AF."
31700166
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"The inhibition of UCHL1 by LDN (a specific inhibitor) significantly reduced the Ang II-induced increase in blood pressure, atrial fibrillation, fibrosis, inflammation, and oxidative stress."
31700166
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"To assess whether UCHL1 mediates post-MI cardiac fibrosis in vivo, we used LDN to inhibit UCHL1."
32606430
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"Both inhibition of UCHL1 by LDN and knockdown UCHL1 by siRNA downregulated TGF-β1-mediated expression of pro-fibrotic proteins in CFs."
32606430
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"In vitro studies verified the LDN-induced inhibition of UCH-L1 had minimal effect on LC3 (a marker of autophagy) in control cells, in cells over expressing a-syn UCH-L1 inhibition resulted in increased LC3 activity."
22514658
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"To demonstrate the efficacy of UCH-L1 inhibition by LDN, neuronal lysates were pre-incubated with increasing amounts of LDN prior to DUB labeling assays."
19535597
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"The mechanism(s) by which inhibition of UCH-L1 by LDN affects its interaction with the members of autophagy pathway are unknown."
22514658