IndraLab

Statements

COPS6 inhibits autophagy. 10 / 10
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"CSN6 promotes the migration and invasion of CC cells through inhibiting autophagy."
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"We found that knockdown of CSN6 induced increased fluorescent protein mRFP+-GFP+-LC3 puncta, suggesting that CSN6 knockdown elicits autophagy flux in CC cells (Fig. 5D)."
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"CSN6 inhibits autophagy by increasing mTOR expression in CC cells."
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"In rice blast fungus, Csn6 deletion leads to enhanced autophagy, which is manifested by an increased number of autophagosomes and an accelerated autophagy rate [26]."
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"These results suggested that CSN6 could inhibit autophagy by increasing mTOR expression in CC cells."
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"Knockdown of CSN6 induced appropriate autophagy pathways and significantly increased LC3-II accumulation in our study.In recent years, autophagy has been reported to be associated with CTSL 26, 31, 32."
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"Interestingly, our results indicated that autophagy is essential for decreasing CTSL, while CSN6 could inhibit the autophagy ability of CC cells."
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"Knockdown of CSN6 enhances autophagy in CC cells."
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"In addition, blocking of the mammalian target of rapamycin (mTOR) pathway reversed CSN6-mediated autophagy inhibition."
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"Endogenous LC3-II turnover blocked by autophagy inhibitor Chloroquine indicated that knockdown of CSN6 induced the normal flux of complete autophagy."
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