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5Z-7-oxozeaenol inhibits MAP3K7. 23 / 28
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"In addition, inhibition of TAK1 by 5Z-7-oxozeaenol blocked TNFα-mediated NFκB signalling, and its downstream genes related to angiogenesis and inflammation."
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"Moreover , pharmacological inhibition of TAK1 by 5Z-7-oxozeaenol attenuated angiogenic activities of endothelial cells ."
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"To further investigate the role of TAK1 in RANK signaling, wildtype BMMs cultured in the presence of RANKL and M-CSF were treated with 5z-7-oxozeaenol, PDTC or FK506, which are inhibitors of TAK1, NF-[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The selective inhibitor of TAK1, 5z-7-Oxozeaenol (5-OZ), reduces inflammatory response by suppressing of MAPK activities [29,30]."
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"However, inhibition of TAK1 by 5Z-7-Oxozeaenol did not prevent TNF-induced necroptotic cell death in Tab2-depleted cells (Fig. 5G, H)."
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"The chemical suppressor of TAK1, 5Z-7-oxozeaenol (5Z7O), was utilised to inactivate TAK1."
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"The CETSA results showed that in DMSO group, TAK1 was completely degraded at 49 °C, while meisoindigo or 5Z-7-Oxozeaenol treatment could inhibit the degradation of TAK1 at 49 °C and increase the therm[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"TAK1 is essential for activation of NFκB signaling and downstream gene expression related to angiogenesis and endothelial activation, as demonstrated in TAK1 knockout human endothelial cells.44 Inhibition of TAK1 by 5Z-7-oxozeaenol, a potent small molecule inhibitor, was found to reduce angiogenesis by suppressing DNA replication and cell cycle, thereby inhibiting cell proliferation."
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"In most cases, a general TAK1 inhibition by 5Z-7-Oxozeaenol, a specific small molecule inhibitor, was used [36, 37]."
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"Importantly, pharmacological inhibition of TAK1 by 5Z-7-oxozeaenol significantly attenuated aberrant retinal angiogenesis in OIR rats.44 Furthermore, 5Z-7-oxozeaenol effectively blocked TNFα-mediated NFκB signaling and downstream gene expression related to angiogenesis and inflammation by inhibiting TAK1 activity46 (Table 1)."
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"In our study, 5Z-7-oxozeaenol almost completely inhibited the activation of TAK1 and its downstream proteins p38, ERK1/2, and JNK1/2, and eliminated the pro-fibrotic effect of TRIM38 knockdown in response to angiotensin II treatment."
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"However, it is important to note that one of the above studies implied that inhibition of TAK1 by 5Z-7-Oxozeaenol could not prevent necroptosis in Tab2-depleted L929 cells [48]."
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"TAK1 is required for GANT61-induced autophagy We next determined if inhibition of TAK1 by 5Z-7-oxozeaenol ( 5Z ) , a TAK1-specific inhibitor , could block GANT61-induced autophagy ."
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"Angiogenic assay further revealed that pharmacological inhibition of TAK1 by 5Z-7-oxozeaenol attenuated angiogenic activities of endothelial cells."
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"The pharmacological inhibitor of TAK1 (TAK1-in), 5Z-7-oxozeaenol, was applied to deactivate TAK1."
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"Inhibition of TAK-1 by 5Z-7-oxozeaenol, a selective TAK-1 inhibitor, attenuated aberrant retinal angiogenesis in the OIR model, with a significant decrease in the number of activated microglia [141]."
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"Methods : Angiogenic activities were assessed in ex vivo and in vitro models subjected to TAK1 inhibition by 5Z-7-oxozeaenol , a selective inhibitor of TAK1 ."
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"Our data also confirmed that VNR-caused NF-κB activation was markedly inhibited by 5Z-7-Oxozeaenol (a specific inhibitor of TAK1) and SB203580 (a specific inhibitor of p38MAPK), further established th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, increased p-TAK1 and TAB1 were substantially reduced by 5Z-7-oxozeaenol in HG-incubated macrophages and in experimental diabetic animals.Clinical studies have indicated that the increase of [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, TAK1 inhibition by 5Z-7-oxozeaenol in OIR rats significantly reduced cytokines expression and adhesion of microglia to retinal endothelial cells."
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"These data suggest that TAK1 inhibition by 5Z-7-oxozeaenol may more specifically attenuate active angiogenesis with less risk of damage to normal endothelial cells."
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"Moreover, TAK1 inhibition by 5Z-7-oxozeaenol is known to block proinflammatory signaling by selectively inhibiting TAK1 MAPKKK [29] ."
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"In addition , inhibition of TAK1 by 5Z-7-oxozeaenol blocked TNFalpha-mediated NFkappaB signalling , and its downstream genes related to angiogenesis and inflammation ."
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