IndraLab

Statements

TNF activates USP18. 7 / 8
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"USP18 is induced in hepatocytes by LPS and TNF-alpha but not by IL-6 and IL-10."
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"FIG 5 : IFN-alpha , LPS , and TNF-alpha do not induce type 1/2 IFN in primary murine hepatocytes but do induce USP18 ."
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"Usp18 is remarkably induced by type I and III IFNs , polyinosinic:polycytidylic acid (poly I:C) , tumor necrosis factor alpha (TNFα) , LPS , or genotoxic stresses ."
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"As seen in Fig. 7A and as described in Table 1 , TNF-alpha induced expression of USP18 was potently downregulated by all inhibitors tested , and this inhibition coincided with impaired IL-1beta mRNA expression ( Fig. 7B ) ."
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"These data suggest that the induction of USP18 by TNF-alpha and LPS , and possibly other inflammatory stimuli , is promoted by NF-kappaBeta signaling and that hepatocyte USP18 expression in particular - - compared to IL-1beta - - may be an attractive target for pharmacologic manipulation in the setting of liver inflammation ."
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eidos
"FIG 1 : USP18 expression is upregulated by TNF-alpha and LPS ."
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reach
"These data suggest that the induction of USP18 by TNF-alpha and LPS, and possibly other inflammatory stimuli, is promoted by NF-kappaBeta signaling and that hepatocyte USP18 expression in particular -- compared to IL-1beta -- may be an attractive target for pharmacologic manipulation in the setting of liver inflammation."
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