IndraLab

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TNF activates USP18. 13 / 14
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"These data suggest that the induction of USP18 by TNF - and LPS , and pos-sibly other inflammatory stimuli , is promoted by NF - > signaling and that hepatocyte USP18 expression in particular-compared to IL-1 - may be an attractive target for pharmacologic manipulation in the setting of liver inflammation ."
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"These data suggest that the induction of USP18 by TNF-alpha and LPS, and possibly other inflammatory stimuli, is promoted by NF-kappaBeta signaling and that hepatocyte USP18 expression in particular -- compared to IL-1beta -- may be an attractive target for pharmacologic manipulation in the setting of liver inflammation."
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"These data suggest that the induction of USP18 by TNF-alpha and LPS , and possibly other inflammatory stimuli , is promoted by NF-kappaBeta signaling and that hepatocyte USP18 expression in particular - - compared to IL-1beta - - may be an attractive target for pharmacologic manipulation in the setting of liver inflammation ."
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"USP18 is induced in hepatocytes by LPS and TNF-alpha but not by IL-6 and IL-10."
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"As seen in Fig. 7A and as described in Table 1 , TNF-alpha induced expression of USP18 was potently downregulated by all inhibitors tested , and this inhibition coincided with impaired IL-1beta mRNA expression ( Fig. 7B ) ."
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"These data suggest that the induction of USP18 by TNF-α and LPS, and possibly other inflammatory stimuli, is promoted by NF-κΒ signaling and that hepatocyte USP18 expression in particular—compared to IL-1β—may be an attractive target for pharmacologic manipulation in the setting of liver inflammation.In this study we examined the role of various inflammatory stimuli in the induction of USP18 and the downstream establishment of an IFN-α refractory state."
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"FIG 1 : USP18 expression is upregulated by TNF-alpha and LPS ."
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"We suspect that whereas increased TNF - does contribute to USP18 expression , there are other stimuli , for example , LPS and perhaps the recently described interferon-lambda 4 ( 56 ) , that also modulate hepatic USP18 expression ."
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"USP18 expression is upregulated by TNF - and LPS ."
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"FIG 5 : IFN-alpha , LPS , and TNF-alpha do not induce type 1/2 IFN in primary murine hepatocytes but do induce USP18 ."
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"19 The Usp18 gene is rapidly and strongly upregulated after viral infection or by type I and type III IFNs, 1, 6, 13, 19, 20 lipopolysaccharide (LPS), 21, 22 tumor necrosis factor alpha (TNF-α), 22 or genotoxic stress 13, 23 (Figure 2a )."
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"The expression of USP18 is strongly induced by type I and type III interferons [ 2-5 ] , by the Toll-like receptor ( TLR ) agonists LPS [ 6-8 ] and polyI :C [ 6 ] ( synthetic analogy of dsRNA ) and by TNFalpha [ 7 ] ."
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"We next sought to determine whether TNF - and LPS could induce USP18 expression in hepatocytes via the induction of IFN - ."
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