IndraLab

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SOS1 activates USP22. 6 / 6
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"These findings suggest that SOS1/RAS and downstream ERK and PI3K/AKT pathways mediate the oncogenic role of USP22 in gastric cancer."
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"Knockdown of SOS1 reverses the oncogenic effects of USP22 in gastric cancer cells."
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"Furthermore, SOS1 silencing could reverse the effects of USP22 on gastric cancer cell behavior and RAS signaling both in vitro and in vivo."
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"Furthermore, SOS1 upregulation in USP22-overexrpessing gastric cancer cells and xenograft tumor tissue is accompanied by activation of the RAS/ERK and RAS/PI3K/AKT pathways, which is attenuated by SOS1 silencing."
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"These results suggest that SOS1/RAS signaling mediates the oncogenic role of USP22 in gastric cancer."
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"Furthermore, our study indicated that SOS1 was upregulated in USP22-overexpressing gastric cancer cells and xenograft tumor tissue, accompanied by activation of the RAS/ERK and PI3K/AKT pathways, suggesting that SOS1/RAS signaling mediates the oncogenic role of USP22 in gastric cancer."
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