IndraLab

Statements

ADAR activates USP38. 6 / 6
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"Structural predictions suggest that ADAR and USP38 interact within their enzymatic activity domains, raising the question of whether ADAR induces conformational changes in USP38 to modulate its enzymatic activity."
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"ADAR can enhance the protein stability of USP38 and upregulate USP38."
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"In conclusion, we show that ADAR enhances USP38 protein stability by interacting with it, and overexpression of USP38 rescues the inhibitory effect of ADAR knockdown on ESCC cell proliferation."
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"ADAR enhances the stability of USP38 protein."
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"The results of nucleo-cytoplasmic separation also indicated that overexpression of ADAR enhanced the accumulation of USP38 in the nucleus (Fig. 3E)."
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"Indeed, protein stability analysis results showed that, compared to control, overexpression of ADAR enhanced USP38 protein stability (Fig. 3H)."
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