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OTUB1 binds IRS4. 7 / 7
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sparser
"The results showed that OTUB1 binding to IRS4 decreased with PILRB deficiency (Fig. xref )."
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sparser
"We then sought to explore whether PILRB regulated the deubiquitination of IRS4 by impacting IRS4 binding to OTUB1."
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sparser
"The results showed that OTUB1 might potentially interact with IRS4."
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sparser
"To validate which deubiquitinase binds to IRS4, we transfected V5-OTUB1/USP9X and FLAG-IRS4 vectors into HEK293T cells and performed immunoprecipitation-western blotting, which showed that only OTUB1 could bind to IRS4 (Fig. S xref )."
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biogrid
No evidence text available
26752685
sparser
"We confirmed the interaction between endogenous OTUB1 and IRS4 in AGS and HGC-27 cells using immunoprecipitation-western blotting, demonstrating the interaction between PILRB and OTUB1 (Fig. xref )."
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sparser
"We also explored whether the interaction between OTUB1 and IRS4 was influenced by PILRB and found that OTUB1 bound to IRS4 was significantly increased by MYC-PILRB (Fig. xref )."
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