IndraLab

Statements



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"FK506 caused a 30-40% reduction in nuclear p65 and a more pronounced reduction (70-80%) of nuclear cRel, p50, and NFATc."

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"Furthermore, FK506 inhibited nuclear factor-kappaB activation and decreased mRNA levels of the p50 and p65 subunits of nuclear factor-kappaB."

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"Finally, at the nuclear level, tacrolimus specifically prevents NF-κB subunits RelA, p50, c-Rel and other members from entering the nucleus [150] ."