IndraLab

Statements

USP4 inhibits CTNNB1. 4 / 4
| 4
reach
"In this study, we found ubiquitin specific peptidase 4 (USP4) to strongly inhibit the Wnt and beta-catenin signaling by removing Lysine 63 linked poly-ubiquitin chain from Dishevelled (Dvl)."
27128386
reach
"As shown in Fig 3J, restoration of USP4 effectively reversed FBXO3 knockdown-mediated down-regulation of Twist1 and β-catenin."
38134227
reach
"Furthermore, silencing of USP4 rescued p110α -mediated up-regulation of Twist1 and β-catenin, accompanied with reduced cell migration (Figs 6F–6H, S5C, and S5D)."
38134227
reach
"Consistently, wild-type FBXO3- or FBXO3 - mediated the up-regulation of Twist1 and β-catenin could be rescued by silencing of USP4 in MDA-MB-231 or Hs578T cells (Figs 3K and S2D)."
38134227