IndraLab

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OTUD5 activates SLC38A1. 4 / 4
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"Therefore, our results suggest that OTUD5 promotes HCC cell proliferation by increasing the stability of SLC38A1."
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"We found that OTUD5 knockdown led to faster SLC38A1 degradation and that OTUD5 overexpression prolonged the half-life of SLC38A1 in HCC cells (P < 0.05, Fig. 6B and C and Supplementary Fig. 4B and 4 C)."
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"OTUD5 knockdown significantly reduced the IHC score of SLC38A1 in xenograft tumour tissues (P < 0.05, Supplementary Fig. 2)."
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"The SLC38A1 protein was the most strongly downregulated by OTUD5 knockdown (Fig. 5A and Supplementary Table 2)."
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