IndraLab

Statements

STAMBP translocates to the endosome. 5 / 5
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"In yeast, this deubiquitination step is carried out by the DUB hydrolase, Doa4 [66] , while in mammals the situation is more complex: two DUBs, USP8 (Ub Specific Protease 8, also called UBPY) and AMSH[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Recruitment of both AMSH and USP8 to endosomes relies on binding to a distinct, but overlapping set of ESCRT III proteins via their respective MIT domains [168,173,174] ."
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"When coexpressed with HA-STAM, we observed a dramatic recruitment of GFP-AMSH (D348A) to endosomes, effectively draining the nuclear pool (B, d–f)."
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"The JAMM class enzyme AMSH is recruited to endosomes by the adaptor protein STAM [55] ."
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"AMSH and UBPY are recruited to endosomes by interactions between their N-terminal MIT domains and late-acting ESCRT-III subunits [ 54–56,57 • ,59 ]."
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