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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Serine-phosphorylated IRS1 decreases the amount of IRS1. 2 / 2

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"Hyperphosphorylation of IRS-1 at several serine residues by kinases including mTORC1 and S6K suppresses IRS-1 expression and function and may be a critical event in insulin resistance (Leibowitz et al[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"The phosphorylation of serine in IRS-1 may suppress insulin signaling by downregulating the expression of the IRS1 protein through ubiquitination [XREF_BIBR], thereby inhibiting the interaction between the insulin receptor and IRS1 phosphotyrosine binding domain [XREF_BIBR, XREF_BIBR]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...