IndraLab

Statements

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"Further, we found that CSN5 enhances viability and metastasis of RCC cells by promoting the process of EMT."
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"Furthermore, we found that knockdown of CSN5 inhibited the metastasis abilities and EMT of RCC cells."
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"In renal cell carcinoma, CSN5 promotes EMT and metastasis through inhibition of ZEB1 degradation (14)."
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"Recently, CSN5-mediated stabilization of ZEB1 promotes renal cell carcinoma migration and invasion by inducing epithelial-mesenchymal transition [ 11 ]."
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"Here, we found that CSN5 promotes the process of EMT by increasing ZEB1 expression in RCC cells."
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"Moreover, our results demonstrated that CSN5 led to the metastasis and EMT activation of RCC cells through upregulation of ZEB1."
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"Overall, these results demonstrate that CSN5 contributes to RCC cell's metastasis and EMT by increasing ZEB1 expression.As dysregulation of CSN5 upregulated or downregulated ZEB1 protein but not ZEB1 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Zhang et al reported that CSN5 promoted renal cell carcinoma EMT by repressing ZEB1 degradation."
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"Previous studies have shown that CSN5 led to the metastasis and EMT activation of cancer cells through decreasing ZEB1 ubiquitination XREF_BIBR."
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