IndraLab

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Tetrodotoxin inhibits FOS. 4 / 4
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"In contrast, tetrodotoxin abolished induction of c-fos and zif268 messenger RNAs by the D2 antagonist eticlopride (0.5 mg/kg, i.p.) in both intact rats and dopamine depleted rats receiving continuous D2 agonist treatment (quinpirole, 0.5 mg/kg/day)."
10077330
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"Application of the Na + channel blocker TTX during stimulation blocked c-Fos induction, indicating that spiking activity was necessary to trigger the signaling cascade leading to c-Fos expression (XREF_FIG)."
19997631
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"In sciatic nerve-ligated rats, TTX administration prevented the increased c-Fos immunoreactivity occurring in the dorsal horn of the lumbar cord and some supraspinal areas in response to light mechanical stimulation of the nerve-injured hindpaw."
19747496
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"C-Fos induction was blocked by TTX but not by AMPA or NMDA receptor antagonists, suggesting that c-Fos upregulation requires action potential firing, but not excitatory synaptic input."
19997631