IndraLab

Statements

USP15 inhibits Neoplasms. 3 / 3
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"Interference with USP15 expression reversed tumor progression and distal colonization in vivo."
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"These proteins level changes revealed the mechanism by which USP15 represses tumor growth."
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"As such, Usp15 appears to function as a double-edged sword in pancreatic cancer, where the loss of Usp15 enhances tumor progression in the initial stages of tumorigenesis but sensitizes to certain treatment regimens in the later stages.Given the wide range of USP15 substrates and USP15-regulated pathways with well-known functions in cancer, we set out to elucidate USP15’s exact role in PDAC suppression."
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