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USP12 activates Hypertrophy. 8 / 8
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"Lu et al. revealed that USP12 promoted Ang II-induced cardiomyocyte hypertrophy; METTL3 expression was induced by Ang II but was downregulated in USP12 knockdown neonatal rat cardiomyocytes (NRCMs)."
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"We found that USP12 promoted Ang II-induced cardiomyocyte hypertrophy, and USP12 deficiency attenuated cardiac hypertrophy in mice."
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"These results describing above confirmed that USP12 aggravates Ang II-induced cardiomyocyte hypertrophy via regulating METTL3.Next, we sought to figure out the molecular mechanism by which USP12 regul[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"According to a recent study, USP12 (ubiquitin-specific protease 12) via enhancing p300/MTLL3 axis promote myocardial hypertrophy [61], and our finding may indicate the possibility of m A methylation and ubiquitination cooperatively regulate heart growth."
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"Collectively, these findings indicated that USP12 was increased in Ang II-induced cardiac hypertrophy and may play a role in the pathogenesis of cardiac hypertrophy.To determine the role of USP12 in A[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"As shown in Fig. 2 B–D, the expression levels of fetal genes and the size of cardiomyocyte were reduced in USP12-silenced NRCMs, indicating that USP12 inhibition could attenuate Ang II-induced cardiom[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Next, we evaluated the effect of USP12 knockout on cardiac hypertrophy, the results showed that USP12 deletion attenuated the phenotype of Ang II-induced cardiac hypertrophy ( Fig. 2 I and J)."
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"Our study demonstrated that USP12 promoted Ang II-induced cardiac hypertrophy via regulating METTL3 expression."
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