IndraLab

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SCN5A activates pH reduction. 4 / 4
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"Inhibition of NaV1.5 by TTX prevented phagocytosis, sodium efflux and endosomal acidification [28] ."
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"An alternative DCM causing mechanism is cardiomyocyte acidification induced by a mutation in SCN5A that causes an H + leak through the mutated channel [73]."
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"Recent work demonstrated that human macrophage NaV1.5, an intracellular voltage gated sodium channel expressed on late endosomes, enhances endosomal acidification and phagocytosis."
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"Rather, NaV1.5 enhanced the acidification of the extracellular perimembrane environment, creating a locally favorable milieu for the activity of extracellular matrix-degrading acidic cathepsins ( Fig.[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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