IndraLab

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SNAI1 inhibits CYLD. 3 / 7
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"10 In basal cell carcinoma, the mechanism for increased SNAI1 mediated repression of CYLD is with the Sonic hedgehog transcription factor GLI1."

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"In skin cancers such as basal cell carcinoma and melanoma, CYLD was repressed at the transcriptional level by the activation of Snail [XREF_BIBR, XREF_BIBR]."

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"Adding to this, it has been shown that CYLD is downregulated by Snail in malignant melanomas [XREF_BIBR]."