IndraLab

Statements

Acetic acid inhibits MYD88. 4 / 4
| 4
reach
"In 2010, Villa et al. reported a natural product named malyngamide F acetate, extracted from marine cyanobacterium Lyngbya majuscule, that selectively inhibits MyD88 dependent pathways involving TLR4 and TLR9 [XREF_BIBR]."
26899347
reach
"Furthermore, engagement of TLR3 (Poly I : C treatment) with and without malyngamide F acetate treatment did not change the transcription of TNF-alpha and IL-10 indicating that malyngamide F acetate selectively inhibits the MyD88 dependent pathway."
20006962
reach
"If malyngamide F acetate is indeed inhibiting the MyD88 dependent pathway then activation of TLR9, which is exclusively activated by CpG and depends solely on the MyD88 dependent pathway, would deliver a biological response with lower levels of TNF-alpha and IL-10 transcripts."
20006962
reach
"Additional experiments utilizing CpG and Poly I : C stimulation to selectively activate the MyD88 dependent and -independent pathways via TLR9 and TLR3 substantiated the finding that malyngamide F acetate selectively inhibits the MyD88 dependent pathway."
20006962