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Mutated KCNH2 activates fluconazole. 1 / 1
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"Each of these genes are linked to drug resistance or the oxidative stress response; for example, ERG1 mutants have increased fluconazole susceptibility in Candida glabrata, ERG25 has a moderate susceptibility to hypoxia and the endoplasmic reticulum (ER) stress inducing agent dithiothreitol (DTT) in Aspergillus fumigatus, and SRE1 is required for hypoxic induction of genes coding for oxygen dependent enzymes involved in ergosterol synthesis in C. neoformans."